New dry powder inhaler

ABSTRACT

A novel dry powder inhaler. By providing a plurality of capsule chambers (1a, 1b, 1c, 1d) arranged in parallel in a capsule dry powder inhalation device, a medicine dispenser containing active components of a composite product or their mixture separately is provided. The dry powder inhaler has a simple structure and is convenient to operate. In addition, the parameters of air inlet channels and an air outlet channel can be adjusted by means of each capsule chamber (1a, 1b, 1c, 1d) according to the properties of powder of a medicine or a combination, so as to provide an appropriate particle distribution for each active component.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of International Application No.PCT/CN2018/116942, filed on Nov. 22, 2018, which claims priority toChinese Patent Application No. 201711177647.1, entitled “New Dry PowderInhaler”, filed on Nov. 21, 2017, both of which are hereby incorporatedby reference in their entireties.

TECHNICAL FIELD

The invention belongs to the field of medical device, and relates to anew dry powder inhaler, especially relates to a capsule dry powderinhaler.

BACKGROUND

The use of dry powder inhalers (DPI) for the treatment of bronchiectasisis well known, wherein the DPI is usually driven by the patient'srespiration and disperses the drug into inhalable powder by aerodynamicmethod.

The capsule dry powder inhaler is a well-known dry powder inhaler, whichcomprises a capsule chamber and an actuator for opening the capsulechamber. The opening of the capsule is mainly achieved by shearingforce, acupuncture or cutting, wherein the acupuncture is the mostcommon opening mechanism, such as the capsule inhaler disclosed in U.S.Pat. No. 8,196,578 B2.

For the capsule DPI of the acupuncture mechanism, the powder containedin the capsule is released by piercing the capsule during atomization.When the patient inhales to generate sufficient airflow, the capsulestarts to rotate and vibrate in the capsule chamber. As the inspiratoryflow increases, the rotate speed of the capsule will increase, therebygenerating sufficient centrifugal force to release the powder from thecapsule. Therefore, the capsule DPI also has the problem of insufficientinspiratory flow for patients with impaired ability to producesufficient inspiratory flow, and is generally not recommended forchildren under 5 and patients with impaired respiratory function.

In addition, combination therapies involving different and complementaryactive ingredients are also known. Currently, not only two, but alsothree or four active ingredients combination therapies have emerged.Although combination products provide additional convenience forpatients, some pharmaceutical active ingredients are difficult toformulate into a single combination product. For example, whenformulated together, the active ingredients may chemically interact witheach other to have a negative effect.

The applicant has found that a capsule dry powder inhaler provides aneffective method to solve the above-mentioned problems. The capsule drypowder inhaler comprises at least two capsule chambers and actuatorsmatching the number of capsule chambers, each capsule chamber is loadedwith capsules containing different pharmacologically active ingredients.By mixing the powder released from the capsules in different capsulechambers, a combined inhalation medicinal product can be provided to thepatient.

SUMMARY

First, this application provides a powder release device for inhalationadministration, comprising:

a capsule chamber, which is a cylindrical chamber that can hold thecapsule upright, and the top of the capsule chamber is open;

an actuator, which comprises a needle, mounted to be movable toward theside wall of the capsule chamber to puncture the capsule, and at leastone part of the actuator is located outside of the dry powder inhalerfor manipulation by the user;

a nozzle, with an outlet duct extending from the top to the bottom, ascreen cover is mounted at the bottom of the outlet duct, the screencover is embedded with a screen, and detachably connected to the top ofthe capsule chamber to cover the top of the capsule chamber;

wherein, the capsule chamber is provided at its bottom and/or side wallwith a deflected intake duct group ventilating with the outside air, thedeflected intake duct group comprises at least two deflected intakeducts which are arranged around the central axis of the capsule chamber,simultaneously deflect clockwise or counterclockwise, in order toprovide a spiral airflow that flows upward from the deflected intakeducts when the user inhales.

Preferably, the deflected intake ducts of the deflected intake ductgroup have the same shape and size, and are evenly arranged around thecentral axis of the capsule chamber.

Preferably, the lower side of the screen protrudes toward the capsulechamber.

Preferably, the bottom of the capsule chamber is provided with intakeducts opened upward and ventilating with the outside air to provide airflow from bottom to top.

Preferably, the capsule chamber is provided at the bottom or the lowerpart of the side wall thereof with intake ducts, which are opened upwardand ventilating with the outside air to provide a through airflow frombottom to top, and the capsule chamber is provided at the bottom and/orthe side wall thereof with a deflected intake duct group to provide aspiral airflow rotating around the capsule chamber.

Further preferably, the intake duct at the bottom of the capsule chamberis opened upward along the central axis of the capsule chamber.

Further preferably, the intake ducts at the bottom of the capsulechamber form a deflected intake duct group.

Further preferably, the deflected intake duct group is arranged at thebottom as a fixed impeller as a whole.

Further preferably, the opening of the deflected intake ducts is tangentto the side wall of the capsule chamber.

Preferably, the side wall of the capsule chamber is provided with adeflected intake duct group.

Further preferably, the lower and/or middle part of the side wall of thecapsule chamber is provided with a deflected intake duct group.

Further preferably, the lower part of the side wall of the capsulechamber is provided with a deflected intake duct group.

Further preferably, the opening of the deflected intake duct is tangentto the side wall of the capsule chamber.

Further preferably, the opening of the deflected intake duct of the sidewall of the capsule chamber has a long-strip shape, which is arrangedlongitudinally along the side wall of the capsule chamber.

Further preferably, the opening of the deflected intake duct of the sidewall of the capsule chamber has a long-strip shape parallel to thecentral axis of the capsule chamber.

Preferably, a deflected intake duct group composed of two deflectedintake ducts is provided in the lower part and/or the middle of the sidewall of the capsule chamber, and an intake duct is provided at thebottom of the capsule chamber.

Preferably, a deflected intake duct group composed of two deflectedintake ducts is provided at the lower part of the side wall of thecapsule chamber and a direct intake duct is provided at the bottom ofthe capsule chamber.

Preferably, the diameter of the capsule chamber is 1.1 to 2.5 times thatof the capsule, and the height of the capsule chamber is 1.02 to 2.0times that of the capsule.

Further preferably, the diameter of the capsule chamber is 1.2 to 1.5times that of the capsule, and the height of the capsule chamber is 1.05to 1.3 times that of the capsule.

In a specific embodiment of this application, the diameter of thecapsule chamber is 1.35 times that of the capsule and the height of thecapsule chamber is 1.15 times that of the capsule.

Preferably, the side wall of the capsule chamber is provided with afirst deflected intake duct group, and the bottom of the capsule chamberis provided with a second deflected intake duct group.

In another aspect, this application provides a method for releasinginhalable powder, comprising the following steps:

(1) Pack the capsule into a cylindrical capsule chamber that can holdthe capsules upright;

(2) Cover the screen cover to the top of the capsule chamber, so thatthe nozzle is connected to the top of the capsule chamber through itsoutlet duct below it;

(3) Puncture the capsule;

(4) Inhale at the nozzle to create the following airflow in the capsulechamber: a) bottom-to-top through airflow that enters through the intakeduct at the bottom of the capsule chamber or the deflected intake ductgroup at the lower part of the side wall and exits from the top of thecapsule chamber; b) a spiral airflow that enters through the deflectedintake duct group at the bottom and/or side wall of the capsule chamberand exits from the top of the capsule chamber, the through airflow andthe spiral airflow together promote the rotation and vibration of thecapsule in the capsule chamber to release the inhalable powder.

Preferably, in the step (4), inhale at the nozzle to create thefollowing airflow in the capsule chamber: a) a bottom-to-top throughairflow that enters through the intake duct at the bottom of the capsulechamber and exits from the top of the capsule chamber and b) a spiralairflow that enters through the deflected intake duct group through theside wall of the capsule chamber and exits from the top of the capsulechamber, the through airflow and the spiral airflow together promote therotation and vibration of the capsule in the capsule chamber to releasethe inhalable powder.

Preferably, this application provides a method for releasing theinhalable powder in the capsule using the powder release device asdescribed in the first part.

The method for releasing inhalable powder of this application can createa spiral airflow when the user inhales, which reduces the starting flowrate of the capsule to release the inhalable powder, enables the user toprovide less inspiratory flow to allow the capsule to rotate and vibrateat high speed to release the drug power, and provides a way for childrenunder 5 and patients with impaired respiratory function to use capsuleDPI.

The powder release device of this application can create a spiral airflow through a deflected intake duct in the capsule chamber when theuser inhales, which reduces the starting flow rate of the rotation,allows the user to provide less inspiratory flow to make the capsulerotate at high speed to release the drug, and provides a way forchildren under 5 years of age and patients with impaired respiratoryfunction to use capsule DPI.

In a third aspect, this application provides a dry powder inhaler,comprising:

capsule chambers, which are cylindrical chambers that can hold thecapsule upright, the top of the capsule chambers is open, and the bottomand/or the side walls of the capsule chambers are provided with intakeducts ventilating with the outside air;

actuators, comprising puncture needles, mounted for the user to operateto move toward the side walls of the capsule chambers to puncture thecapsules;

nozzle, comprising an outlet duct under the nozzle;

wherein, the number of the capsule chambers is two to four, and all thecapsule chambers are arranged in parallel to form an integralmulti-capsule chamber, the actuators are mounted individually or incommon among the capsule chambers, and the actuators are mounted withneedles in the width direction of the actuators, at least the number ofthe needles is same as that of matching capsule chambers, a screen coveris mounted at the bottom of the outlet duct under the nozzle, and ascreen is fixed in the screen cover, and separately connected to the topof the multi-capsule chamber, making the screen cover the top of all ofthe capsule chambers.

Preferably, the side wall of the outlet duct is provided with at leastone small hole ventilating with the outside air, and the small hole isopened in a direction not facing the central axis of the outlet duct topromote airflow rotate in the outlet duct when the user inhales.

Preferably, the diameter of the outlet duct gradually decreases frombottom to top, and a narrow neck is formed before arriving at thenozzle, and the small hole of the outlet duct is provided at the lowerside of the narrow neck.

Further preferably, the number of the small holes in the side wall ofthe outlet duct is two, the two small holes are symmetrically openedaround the central axis of the outlet duct.

Preferably, an intake duct is provided at the bottom of each capsulechamber to provide air flow from bottom to top when the user inhales.The intake duct opens upward and ventilates with outside air.

Further preferably, the intake duct at the bottom of each capsulechamber comprises a deflected intake duct group, the deflected intakeduct group comprises at least two deflected intake ducts which arearranged around the central axis of the capsule chamber, simultaneouslydeflect clockwise or counterclockwise, in order to provide a spiralairflow that flows upward from the bottom when the user inhales.

Further preferably, the intake ducts at the bottom of each capsulechamber is a deflected intake duct group, the deflected intake ductgroup comprises at least two deflected intake ducts which are arrangedaround the central axis of the capsule chamber, simultaneously deflectclockwise or counterclockwise, in order to provide a spiral airflow thatflows upward from the bottom when the user inhales.

Further preferably, the deflected intake ducts of the deflected intakeduct group of each capsule chamber have the same shape and size, and areevenly arranged around the central axis of the capsule chamber.

Further preferably, the opening of the deflected intake ducts at thebottom of the capsule chamber is tangent to the side wall of the capsulechamber.

In a specific embodiment of this application, the deflected intake ductat the bottom of each capsule chamber is arranged as a fixed impeller asa whole.

Preferably, the side wall of each capsule chamber is provided with adeflected intake duct group, the deflected intake duct group comprisesat least two deflected intake ducts which are arranged around thecentral axis of the capsule chamber, simultaneously deflect clockwise orcounterclockwise, in order to provide a spiral airflow that flows upwardfrom the bottom when the user inhales.

Further preferably, the deflected intake duct group is provided in themiddle and/or lower part of the side wall of the capsule chamber.

Further preferably, the deflected intake duct group is provided at thelower part of the side wall of the capsule chamber.

Further preferably, the deflected intake ducts in a deflected intakeduct group have the same shape and size, and are evenly arranged aroundthe central axis of the capsule chamber.

Further preferably, the opening of the deflected intake duct is tangentto the side wall of the capsule chamber.

Further preferably, the opening of the deflected intake duct of the sidewall of the capsule chamber has a long-strip shape, which is arrangedlongitudinally along the side wall of the capsule chamber.

Further preferably, the opening of the deflected intake duct of the sidewall of the capsule chamber has a long-strip shape parallel to thecentral axis of the capsule chamber.

Further preferably, the number of deflected intake ducts of a deflectedintake duct group is two.

In a specific embodiment of this application, a deflected intake ductgroup composed of two deflected intake ducts is provided at the lowerpart of the side wall of the capsule chamber, and an intake duct isprovided at the bottom of the capsule chamber.

Preferably, the size of the intake duct and/or top opening of at leastone capsule chamber is different from that of other capsule chambers, sothat the air flow rate in the capsule chamber is different from that ofthe other capsule chambers.

Further preferably, the size of the intake duct of at least one capsulechamber is different from that of other capsule chambers, so that theair flow rate in the capsule chamber is different from that of the othercapsule chambers.

Preferably, the diameter of the capsule chamber is 1.1 to 2.5 times thediameter of the capsule, and the height of the capsule chamber is 1.02to 2.0 times the height of the capsule.

Further preferably, the diameter of the capsule chamber is 1.2 to 1.5times the diameter of the capsule, and the height of the capsule chamberis 1.05 to 1.3 times the height of the capsule.

In a specific embodiment of the invention, the diameter of the capsulechamber is 1.35 times the diameter of the capsule and the height of thecapsule chamber is 1.15 times the height of the capsule.

Preferably, the multi-capsule chamber is composed of a first capsulechamber and a second capsule chamber, a first actuator and a secondactuator are arranged at both ends of the connecting line where thefirst capsule chamber and the second capsule chamber are located, thefirst actuator and the second actuator can move from both sides to themiddle so as to puncture the capsules in the first capsule chamber andthe second capsule chamber, respectively.

Preferably, the multi-capsule chamber is composed of first capsulechamber and a second capsule chamber, which are closely arranged, afirst actuator and a second actuator are arranged at both ends of a lineconnecting the first capsule chamber and the second capsule chamber, thefirst actuator and the second actuator can move from both sides to themiddle so as to puncture the capsules in the first capsule chamber andthe second capsule chamber, respectively.

Preferably, the multi-capsule chamber is composed of first capsulechamber and second capsule chamber, which are closely arranged, and anactuator is arranged on one side of the line connecting the firstcapsule chamber and the second capsule chamber, the actuator comprisesat least two needles in the width direction to puncture the capsules inthe first capsule chamber and the second capsule chamber at the sametime.

Further preferably, the lower part of the outlet duct is divided by acentral baffle to form a first sub-duct and a second sub-duct, which arerespectively connected to the tops of the first capsule chamber and thesecond capsule chamber, the first sub-duct and the second sub-ductgradually gather from bottom to top from the top of each capsule chambertoward the central baffle, their cross-sections gradually narrow ormaintain, they direct the airflows of the first capsule chamber and thesecond capsule chamber converge to the upper part of the outlet duct,along the first sub-duct and the second sub-duct respectively, when theuser inhales. More preferably, the cross-sections of the first sub-ductand the second sub-duct gradually narrow from the top of each capsulechamber first, and then remain.

Further preferably, the cross-section of the outlet duct maintains thesame size or gradually increases from the top of the central baffletoward the nozzle. Further preferably, the cross-sections of the outletducts gradually increase in a direction from the top of the centralbaffle toward the nozzle first, and then remain.

More preferably, the first sub-duct and the second sub-duct furthercomprise one or more sub-baffles, the one or more sub-baffles divide thefirst sub-duct and the second sub-duct to narrower ducts respectively,which gradually gather from bottom to top from the top of each capsulechamber toward the central baffle. More preferably, the height of thesub-baffle is lower than that of the central baffle. More preferably,the whole shape of the cross-section of the sub-baffles is like “X”,which takes the central baffle as the plane mirror symmetry.

Further preferably, the nozzle is mounted at where the airflow from thefirst capsule chamber and the second capsule chamber has fully convergedin the upper part of the outlet duct along the first sub-duct and thesecond sub-duct respectively when the user inhales.

More preferably, the length of the outlet duct is 25-36 mm, mostpreferably 31 mm.

Further preferably, the air resistance of the dry powder inhaler is0.01-0.08 KPa 0.5 minutes/liter.

More preferably, the air resistance of the dry powder inhaler is0.02-0.05 KPa 0.5 minutes/liter.

In a specific embodiment of this application, the air resistance of thedry powder inhaler is 0.0325 KPa 0.5 minutes/liter.

Preferably, the multi-capsule chamber is closely arranged into atriangle by the first capsule chamber, the second capsule chamber andthe third capsule chamber, and a first actuator is arranged on one sideof the line connecting the first capsule chamber and the second capsulechamber, the first actuator comprises at least two needles in the widthdirection to puncture the capsules in the first capsule chamber and thesecond capsule chamber at the same time, a second actuator is arrangedon the side of the third capsule chamber that far away from the firstcapsule chamber and the second capsule chamber, it is movable in avertical direction of the straight line where the first capsule chamberand the second capsule chamber are located to puncture the capsule inthe third capsule chamber.

Further preferably, the air resistance of the dry powder inhaler is0.015-0.073 KPa0.5 minutes/liter.

More preferably, the air resistance of the dry powder inhaler is0.02-0.04 KPa 0.5 minutes/liter.

In a specific embodiment of this application, the air resistance of thedry powder inhaler is 0.0305 KPa 0.5 minutes/liter.

Preferably, the multi-capsule chamber is closely arranged into a squareby the first capsule chamber, the second capsule chamber, the thirdcapsule chamber and the fourth capsule chamber, and a first actuator anda second actuator are arranged on the central axes of the square andmovable from both sides to the middle, the first actuator and the secondactuator comprise at least two needles in the width direction, so thatthe first actuator punctures the capsules in the capsule chamber and thesecond capsule chamber at the same time, the second actuator puncturesthe capsules in the third capsule chamber and the fourth capsule chamberat the same time.

Further preferably, the air resistance of the dry powder inhaler is0.01-0.06 KPa 0.5 minutes/liter.

Even more preferably, the air resistance value of the dry powder inhaleris 0.015-0.035 KPa 0.5 minutes/liter.

In a specific embodiment of this application, the air resistance of thedry powder inhaler is 0.029 KPa 0.5 minutes/liter.

Preferably, the dry powder inhaler comprises:

a lower casing, which defines a cavity, the tope of which is open and isused for accommodating a multi-capsule chamber inside, the side of thelower casing is provided with gaps that match the number and position ofthe actuators, so that part of each actuator is located outside the drypowder inhaler for the user to operate, and the cavity ventilates withthe outside air;

an adapter plate, which covers the top of the lower casing, and a hollowport is provided at the top of the multi-capsule chamber, a screen coveris detachably mounted to the hollow port so that the screen can coverthe top of each capsule chamber through the hollow port;

an upper casing, which extends downward from the top of the nozzle,defines a cavity surrounding the outlet duct and the bottom of thecavity being open, and covers the adapter plate when the screen cover ismounted at the hollow port.

Preferably, the dry powder inhaler comprises:

a lower casing, which defines a cavity, the tope of which is open and isused for accommodating a multi-capsule chamber inside, the side of thelower casing is provided with gaps, the number and position of whichmatch with the number and position of the actuators, so that at leastone part of each actuator is located outside the dry powder inhaler forthe user to operate, and the cavity ventilates with the outside airthrough an air intake hole provided on the side and/or at the bottom ofthe lower casing;

a adapter plate, which covers the top of the lower casing, and a hollowport is provided at the top of the multi-capsule chamber, a screen coveris detachably mounted to the hollow port so that the screen can coverthe top of each capsule chamber through the hollow port;

an upper casing, which extends downward from the top of the nozzle,defines a cavity surrounding the outlet duct and the bottom thereofbeing open, and covers the adapter plate when the screen cover ismounted at the hollow port.

Preferably, the multi-capsule chamber is formed integrally with theadapter plate, which is fixed below the hollow port of the adapterplate.

Preferably, the gaps are widened and/or extended based on the size ofthe actuator to provide the air intake hole.

Preferably, the side wall of the outlet duct is provided with at leastone small hole ventilating with the outside air, and the small hole isopened in a direction not facing the central axis of the outlet duct topromote airflow rotate in the outlet duct when the user inhales.

Preferably, the upper casing, the lower casing and the adapter plate areconnected together by a hinge on the same side.

Preferably, the adapter plate and the capsule chamber are integrallyformed, and the hollow port constitutes the top opening of each capsulechamber.

Preferably, the diameter of the outlet duct gradually decreases frombottom to top, and a narrow neck is formed before arriving at thenozzle.

Preferably, a slit or a hole is provided at the junction of the uppercasing and the adapter plate, so that the cavity can ventilate with theoutside air through the slit or the hole;

Further preferably, the number of small holes on the outlet duct is two,the two small holes are symmetrically opened around the central axis ofthe outlet duct.

Further preferably, the small holes on the outlet duct are located inthe area below the narrow neck.

The dry powder inhaler of this application provides a medicine dispensercontaining different active components (or a mixture thereof) separatelyby providing a plurality of capsule chambers arranged in parallel. Thestructure is simple and the operation is convenient. In addition, eachcapsule chamber can adjust the parameters of the intake duct and the airexhaust duct according to the nature of the powder of the drug(composition), in order to provide suitable particle distribution foreach active ingredient.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows a disassembled view of the structure of a powder releasedevice of this invention.

FIG. 2 shows a sectional view of a capsule chamber of the powder releasedevice shown in FIG. 1

FIG. 3 shows a cross-sectional top view of the capsule chamber shown inFIG. 2.

FIG. 4 shows another sectional view of the capsule chamber of the powderrelease device shown in FIG. 1.

FIG. 5 shows a structural view of the lower part of the section of thecapsule chamber shown in FIG. 4.

FIG. 6 shows another sectional view of the capsule chamber of the powderrelease device shown in FIG. 1.

FIG. 7 shows a sectional top view of the capsule chamber shown in FIG.6.

FIG. 8 shows another sectional view of the capsule chamber area of thepowder release device shown in FIG. 1.

FIG. 9 shows a sectional top view of the capsule chamber shown in FIG.8.

FIG. 10 is a partially enlarged view of the impeller at the bottom ofthe capsule chamber shown in FIG. 9.

FIG. 11 is a sectional view of another capsule chamber area of thepowder release device shown in FIG. 1.

FIG. 12 shows a sectional top view of the capsule chamber area shown inFIG. 11.

FIG. 13 shows a disassembled view of the structure of a dry powderinhaler of the present invention.

FIG. 14 is a partial cross-sectional view of the dry powder inhalershown in FIG. 13.

FIG. 15 is a perspective view of the nozzle of the dry powder inhalershown in FIG. 13.

FIG. 16 is a perspective view of the screen cover of the dry powderinhaler shown in FIG. 13.

FIG. 17 shows a sectional plan view of the multi-capsule chamber of thedry powder inhaler shown in FIG. 13.

FIG. 18 shows a sectional top view of a multi-capsule chamber of anotherdry powder inhaler of the present invention.

FIG. 19 shows a sectional top view of a multi-capsule chamber of anotherdry powder inhaler of the present invention.

FIG. 20 is a partial sectional view of another dry powder inhaler of thepresent invention.

FIG. 21 is a sectional view of the airflow of the nozzle of the drypowder inhaler shown in FIG. 20.

FIG. 22 is a plan view of the nozzle of the dry powder inhaler shown inFIG. 20.

DETAILED DESCRIPTION OF THE EMBODIMENTS

The present invention will be further described below in conjunctionwith specific embodiments. However, it should not be understood that thescope of the above subject of this application is only limited to thefollowing embodiments, and any technology implemented based on thecontent of this application belongs to the scope of this application.

By referring to FIG. 1, FIG. 2 and FIG. 3, FIG. 1 illustrates a specificembodiment of a powder release device of the present invention,comprising: (a) a capsule chamber 1, which is a cylindrical chamber thatcan receive the capsule, the capsules chamber 1 is provided with anoutlet duct 11 at the top thereof, and a ventilating screen 12 ismounted at the junction of the outlet duct 11 and the capsule chamber 1;(b) the actuator 2, which comprises at least one needle 21, which ismounted as it can move to the capsule chamber 1 to puncture the capsule,and at least one part of the actuator 2 is located outside the powderrelease device for the user to manipulate; (c) the nozzle 3, which isconnected to the top of the capsule chamber 1 through the outlet duct11. By referring to FIG. 2, the capsule chamber 1 is provided with adeflected intake duct group that ventilates with outside air. Byreferring to, the deflected intake duct group comprises at least twodeflected intake ducts 13, which are arranged around the central axis ofthe capsule chamber and simultaneously deflect clockwise orcounterclockwise, in order to provide a spiral airflow that flows fromthe deflected intake duct group to the top outlet duct 11 when the userinhales.

In this embodiment, the user opens the screen 12 mounted above thecapsule chamber 1 first and puts the capsule herein, then presses theactuator 2 to puncture the capsule, and the actuator 2 is then reset bymanual operations or elastic means. Since the nozzle 3 ventilates withthe capsule chamber 1 through an outlet duct 11, and the capsule chamber1 ventilates with the external environment through the deflected intakeduct group, when the user inhales, the outside air passes through thedeflected intake duct group to generate a spiral airflow surrounding thecapsule chamber 1, to promote a rapid rotation of the punctured capsuleto release the inhalable medicinal powder contained therein. Theinhalable medicinal powder moves with the airflow to the outlet duct 11at the top of the capsule chamber 1 and enters the user's body throughthe nozzle 3.

It should be noted that the deflected intake duct 13 of this embodimentis deflected clockwise or counterclockwise, but it does not mean thatthe deflected intake duct group must be opened in the horizontaldirection, as long as it can provide a part of the air flow deflected inthe horizontal direction. Of course, the at least two deflected intakeducts 13 should be deflected simultaneously. For example, when thedeflected intake passages 13 are located on the side wall, they shouldall face diagonally upward, all face diagonally downward, or all facehorizontally.

Compared with the prior art, the powder release device of thisembodiment provides the deflected intake duct group in the capsulechamber 1, so that the requirement of the user's inhalation flow whenthe capsule rotates and releases medicine is greatly reduced, the powderis easier to release and the amount of residue reduces.

The deflected intake ducts 13 of the deflected intake duct group havethe same shape and size, and are evenly arranged around the central axisof the capsule chamber 1 to provide more uniform spiral airflow. Sincethe release of the inhalable powder in the capsule is achieved by therotation and vibration of the capsule in the capsule chamber 1, but notbased on only the rotation, the shapes and sizes of the deflected intakeducts 13 of the deflected intake duct group do not have to be exactlythe same.

Compared with the prior art, the powder release device of thisembodiment provides the deflected intake duct group in the capsulechamber 1, so that the requirement of the user's inhalation flow ratewhen the capsule rotates and vibrates to release medicine is greatlyreduced, the powder is easier to release and the amount of residue isreduced.

Further preferably, by referring to FIG. 1, in one embodiment, the lowerside of the ventilating screen 12 protrudes toward the capsule chamber1, and this shape can provide a capsule rotating contact surface withless resistance.

Further preferably, by referring to FIG. 2 and FIG. 3, in oneembodiment, the deflected intake duct group is provided on the side wallof the capsule chamber 1, and the bottom of the capsule chamber 1 isalso provided with an intake duct 14 ventilating with the outside air,which is opened upwards along the central axis of the capsule chamber 1to provide an air flow throughout the capsule chamber 1 from bottom totop when the user inhales.

In this embodiment, the intake duct 14 at the bottom of the capsulechamber 1 can provide a through airflow throughout the entire capsulechamber 1 from bottom to top when the user inhales, in order to help thetop of the capsule to rotate against the ventilating screen 12 at thetop of the capsule chamber 1, so that the powder released from thecapsules moves toward the top of the outlet duct 11 more smoothly.

In this embodiment, the opening of the deflected intake duct 13 at theside wall of the capsule chamber 1 has a long-strip shape, which isarranged longitudinally along the side wall of the capsule chamber, inorder to provide an airflow having a larger surface contact with thecapsule when the user inhales, so as to drive the capsule to rotate andvibrate easier in the capsule chamber 1 to release the inhalable powder.

Further preferably, by referring to FIG. 2 and FIG. 3, in oneembodiment, the opening of the deflected intake duct 13 at the side wallof the capsule chamber 1 has a long-strip shape which is parallel to thecentral axis of the capsule chamber, so that when the user inhales, anairflow with a larger surface contact with the capsule and a betterapplying force direction is provided to drive the capsule to rotate andvibrate more smoothly in the capsule chamber 1 so as to release theinhalable powder.

Further preferably, by referring to FIG. 4 and FIG. 5, in oneembodiment, the deflected intake duct group is provided at the lowerpart of the side wall of the capsule chamber 1, and the intake duct 14is provided at the bottom of the capsule chamber 1, wherein the intakeduct is opened upwards along the central axis of the capsule chamber 1to provide an air flow throughout the capsule chamber 1 from bottom totop when the user inhales.

The deflected intake duct group is provided at the lower part of theside wall of the capsule chamber 1, which can better provide a throughairflow throughout the entire capsule chamber 1 from bottom to top whenthe user inhales, in order to help the top of the capsule to rotateagainst the ventilating screen 12 at the top of the capsule chamber 1,so that the powder released from the capsule moves toward the top of theoutlet duct 11 more smoothly.

Further preferably, by referring to FIG. 6 and FIG. 7, in oneembodiment, the deflected intake duct group is provided at the lowerpart of the side wall of the capsule chamber 1, and the intake duct 14is not provided at the bottom of the capsule chamber 1.

The deflected intake duct group is only provided at the lower part ofthe side wall of the capsule chamber 1, which can also provide abottom-up airflow when the user inhales, in order to help the top of thecapsule to rotate against the ventilating screen 12 at the top of thecapsule chamber 1. It can be understood that, in order to make the topof the capsule rotate against the screen 12 at the top of the capsulechamber 1, the through airflow is not necessary, as long as anon-through airflow from bottom to top is enough to lift the capsule.

By referring to FIG. 8, FIG. 9 and FIG. 10, in another embodiment of apowder release device of the present invention, a deflected intake ductgroup is provided at the bottom of the capsule chamber 1.

In this embodiment, the deflected intake duct group at the bottom of thecapsule chamber 1 can also be evenly arranged around the central axis ofthe capsule chamber, simultaneously deflect clockwise orcounterclockwise. When the user inhales, it can provide a part of thespiral airflow that is deflected in the horizontal direction to help thecapsule rotate and vibrate to release the inhalable powder, and it canalso provide another part of the bottom-to-up through airflow to helpthe top of the capsule rotate against the ventilating screen 12 at thetop of the capsule chamber 1, so that the powder released from thecapsule moves towards the top of the outlet duct 11 more smoothly. Thestructure is simple, and it serves two purposes.

Further preferably, by referring to FIG. 9 and FIG. 10, in oneembodiment, the deflected intake duct group at the bottom is arranged asa fixed impeller as a whole.

In this embodiment, the deflected intake duct group of the impellerstructure at the bottom of the capsule chamber 1 can be understood asbeing composed of four deflected intake ducts 13 separated by fourblades.

Further preferably, by referring to FIG. 11 and FIG. 12, in oneembodiment, each of the bottom and side walls of the capsule chamber 1is provided with a deflected intake passage group.

In this embodiment, each of the deflected intake duct groups at thebottom of the capsule chamber 1 and those at the side wall serve toprovide deflected airflow, wherein the deflected intake duct groups atthe bottom of the capsule chamber 1 can also provide a bottom-up throughairflow, and the object of the present invention can also be achieved.

By referring to FIG. 13 and FIG. 14, it is an embodiment of a dry powderinhaler of the present invention , comprising: (a) capsule chambers 1(that is, 1 a and 1 b in the FIG), which are cylindrical chambers thatcan hold a capsule upright, the top of the capsule chambers 1 is open,and the bottom of the capsule chambers 1 is provided with intake ducts14 that ventilate with the outside air; (b) actuators 2, which comprisepuncture needles 21, the puncture needles 21 are mounted for the user tooperate to move toward the side walls of the capsule chambers 1 topuncture the capsules; (c) nozzle 3, illustrated in FIG. 13 and FIG. 15,which comprises an outlet duct 11 below the nozzle (for clarity, thelower part of the outlet 11 in FIG. 13 is intercepted and separated fordisplay); wherein, the number of the capsule chambers 1 is two, the twocapsule chambers 1 are arranged in parallel to form an integrally formeddouble-capsule chamber, and the actuators 2 are mounted individuallybetween the capsule chambers 1, each actuator 2 is provided with twoneedles 21 in the height direction, a screen cover 15 is mounted at thebottom opening of the outlet duct 11, by referring to FIG. 16, a screen12 is mounted in the screen cover 15 and can be separately connected tothe top of the double-capsule chamber, so that the screen 12 covers thetops of the two capsule chambers 1.

In this embodiment, the double capsule-chamber is composed of firstcapsule chamber 1 a and second capsule chamber 1 b which are closelyarranged, and the first actuator 2 a and the second actuator 2 b arearranged at both ends of the line where the first capsule chamber 1 aand the second capsule chamber 1 b are located, the first actuator 2 aand the second actuator 2 b can move from both sides to the middle so asto puncture the capsules in the first capsule chamber 1 a and the secondcapsule chamber 1 b, respectively.

The user separates the screen cover 15 from the top of thedouble-capsule chamber first, to make the top of the double-capsulechamber open; after filling the capsule chambers 1 with capsulescontaining different active ingredients, the screen cover 15 is closedto make the screen 12 cover the top of the capsule chambers 1 again;then, the user operates the actuators 2 to move from both sides to themiddle so as to puncture the capsules in the first capsule chamber 1 aand the second capsule chamber 1 b, respectively, and the actuators 2are reset by elastic components commonly used in the prior art; finally,the user covers the mouth to the nozzle 3 closely and inhalesforcefully, and the outside air enters the capsule chambers through theintake duct 14 at the bottom of the capsule chambers 1, so that thecapsules vibrate and rotate against the screen 12 to release the powder.The released powder from the capsules passes through the screen 12 intothe outlet duct 11 and finally enters the human body.

Although the actuators 2 of this embodiment move from both sides to themiddle so as to puncture the capsules in the first capsule chamber 1 aand the second capsule chamber 1 b, respectively, person skilled in theart can adjust the arrangement of the actuators, for example , theactuators 2 are provided on one side of the line where the first capsulechamber 1 a and the second capsule chamber 1 b are located, theactuators 2 comprise at least two needles in the width direction, sothat when operated, the actuators 2 puncture the capsules in the firstcapsule chamber 1 a and the second capsule chamber 1 b at the same time.

Further preferably, by referring to FIG. 17, in one embodiment, the sidewall of each capsule chamber 1 is respectively provided with a deflectedintake duct group. The deflected intake duct group comprises twodeflected intake ducts 13 which are arranged around the central axis ofthe capsule chamber 1, simultaneously deflect clockwise orcounterclockwise, in order to provide a spiral airflow that flows upwardfrom the deflected intake ducts 13 when the user inhales.

Compared with the foregoing embodiment, the inhaler of this embodimentis provided with a deflected intake duct group on the side wall of thecapsule chamber 1 to provide a spiral airflow that moves upward from thedeflected intake duct 13 when the user inhales. The airflow can help thecapsules rotate and vibrate more smoothly to release the inhalablepowder, which greatly reduces the requirement of the user's inhalationflow when the capsules rotate and release medicine, and can release thepowder easier.

Further preferably, by referring to FIG. 13 and FIG. 14, in oneembodiment, the deflected intake duct group is provided at the lowerpart of the side wall of each capsule chamber 1.

Compared with the previous embodiment, the inhaler of this embodimentprovides a deflected intake duct group at the lower part of the capsulechamber 1, which can not only provide a spiral airflow moving upwardfrom the deflected intake duct 13, but also assist the bottom of theintake duct 14 to make the top of the capsule rotate against the screen12 at the top of the capsule chambers.

Further preferably, by referring to FIG. 17, in one embodiment, thedirection of the deflected intake ducts 13 is tangent to the side wallof each capsule chamber 1, so that the spiral airflow can smoothly drivethe capsules to rotate.

Further preferably, by referring to FIG. 20, in one embodiment, thelower part of the outlet duct 11 is divided by a central baffle 111 toform a first sub-duct 11 a and a second sub-duct 11 b, which arerespectively connected to the tops of the first capsule chamber and thesecond capsule chamber, the first sub-duct 11 a and the second sub-duct11 b gradually gather from the bottom to top toward the central baffle111, the cross-sections thereof are gradually narrowed first and thenremain unchanged, so that when the user inhales, the airflows in thefirst capsule chamber 1 a and the second capsule chamber 1 b aredirected along the first sub-duct 11 a and the second sub-duct 11 b tomerge in the upper part of the outlet duct 11 respectively.

By referring to FIG. 21, through the special design of the lower part ofthe outlet duct 11 of this embodiment, when the user inhales, theairflows in the two capsule chambers can be gathered in the area abovethe central baffle 111 and converged, and then be directed to flow abovethe outlet duct, so not only can the drug powder released in the twocapsule chambers be fully mixed, but also can the collision with theduct be reduced, thereby the resistance when user inhales can bereduced.

More preferably, by referring to FIG. 20 and FIG. 21, in one embodiment,the cross-section of the outlet duct 11 gradually increases from the topof the central baffle 111 toward the nozzle 3 and then remainsunchanged. when the user inhales, the airflows in the two capsulechambers(1 a, 1 b) can be gathered in the area above the central baffle111 and converged, and then be directed to flow above the outlet duct,therefore, the cross-section of the outlet duct 11 of the presentembodiment gradually increases from the top of the central baffle 111toward the nozzle 3 and then remains unchanged, which is advantageousfor air to flow upwards more smoothly, as the obstruction of the of theinner wall of the airflow duct 11 to the airflow is reduced and thecollision of the drug powder in the airflow with the inner wall of theoutlet duct 11 is reduced. It can be understood that, in order toachieve the above effect, the cross-section of the outlet duct 11 fromthe top of the central baffle 111 toward the nozzle 3 does notnecessarily gradually increase and then remains unchanged, as long as itdoes not decrease.

More preferably, by referring to FIG. 22, in one embodiment, the firstsub-duct 11 a and the second sub-duct 11 b further comprise twosub-baffles 112, and the first sub-duct 11 a and the second sub-duct 11b are further divided by the sub-baffles 112 into a plurality of narrowducts that gradually gather from the top of each capsule chamber frombottom to top toward the central baffle 111 respectively, the height ofthe sub-baffle 112 is lower than that of the central baffle 111. Thecross-section of the sub-baffles is X-shaped, which ismirror-symmetrical with the central baffle 111 as the symmetry plane.

In this embodiment, the sub-ducts (11 a, 11 b) are further divided intosix narrow ducts, each narrow duct can guide the direction of thegathered airflow more precisely according to its position, so as to makethe airflows from the two capsule chambers (1 a, 1 b) gather moresmoothly and converge on the upper area of the central baffle 111, andthen be directed to flow above the outlet duct.

More preferably, by referring to FIG. 20, in one embodiment, theairflows from the first capsule chamber 1 a and the second capsulechamber 1 b flows along the first sub-channel 11 a and the secondsub-channel 11 b to the upper part of the outlet duct 11 respectivelywhen the user inhales, and the nozzle 3 is provided at a position wherethe airflows are sufficiently converged, and the height of the outletduct 11 is 31 mm.

The height of the outlet duct 11 in this embodiment refers to thedistance from the top of the capsule chamber to the nozzle 3, as shownin FIG. 21, in the vicinity of the nozzle at the end of the outlet duct,the airflow in the two capsule chambers (1 a, 1 b) has been fullyconverged, and the drug powder in the airflow is also fully mixed.Further increasing the distance of the outlet duct will increase theinhalation resistance.

Further preferably, by referring to FIG. 13, FIG. 14 and FIG. 15, in oneembodiment, the dry powder inhaler further comprises:

(d) the lower casing 4, which defines a cavity , the tope of which isopen and is used for accommodating the double-capsule chamber, and thelower casing 4 is provided with two gaps 41 on the side thereof, so thatat least one part of the each actuator 2 is provided located outside ofthe dry powder inhaler for user to operate, the gaps 41 extend downwardand widen with respect to the size of the actuators 2 to provide an airintake 42, so that the inside of the cavity can ventilate with theoutside air through the air intake 42; (e) the adapter plate 5 whichcovers the top of the lower casing 4, and a hollow port 51 is providedat the top of the multi-capsule chamber, and a screen cover 15 isdetachably mounted to the hollow port 51 so that the screen 12 coversthe top of each capsule chamber 1;

(f) the upper casing 6, which extends downward from the top of thenozzle 3, defines a cavity that is open at the bottom and surrounds theoutlet duct 11, and covers the adapter plate 5 when the screen cover 15is mounted at the hollow port.

First, the user separates the lower casing 4 and the upper casing 6 soas to separate the screen cover 15 from the top of the double-capsulechamber, then fills each capsule chambers 1 with capsules containing twodifferent active ingredients, and then closes the upper casing 6 and thelower casing 4 so that the screen 12 covers the top of the capsulechambers 1 again; then, the user operates parts of the actuators 2located out of the casings to puncture the capsules in the capsulechambers 1, the actuators 2 are reset by the elastic components commonlyused in the prior art; finally, the user closely fits the mouth to thenozzle 3 and inhales in force, the outside air enters the cavity throughthe air intake hole 42 of the lower casing 4, and enters the capsulechambers 1 from the intake ducts 14 at the bottom of the capsulechambers 1, so that the capsules vibrate and rotate against the screen12 to release the powder. The released powder from the capsule entersthe outlet duct 11 through the screen 12 and finally enters the humanbody.

Compared with the previous embodiment, the dry powder inhaler of thisembodiment adds the upper casing 6, the lower casing 4 and the adapterplate 5 on the premise of supporting the technical solution of theprevious embodiment, thereby increasing the structural firmness of thedry powder inhaler, and making it easy to operate. The upper casing 6,the lower casing 4 and the adapter plate 5 are all conventionalcomponents of the same type of dry powder inhaler in the prior art. Inthis embodiment, the upper casing 6, the lower casing 4 and the adapterplate 5 are also conventional designs in the prior art.

Further preferably, by referring to FIG. 13, FIG. 14 and FIG. 15, in oneembodiment, a slit 52 is provided at the junction of the upper casing 6and the adapter plate 5, so that the internal cavity can ventilate withthe outside air through the slit 52. The side wall of the outlet duct 11is provided with a small hole 113, which is opened in a direction notfacing the central axis of the outlet duct 11 to promote airflow rotatein the outlet duct 11 when the user inhales.

When the user inhales, external air can enter the internal cavity of theupper casing 6 through the slit and enter the outlet duct 11 from thesmall hole 113 of the outlet duct 11 to promote the rotation of theairflow in the outlet duct 11, in this embodiment, after the capsulemedicine powder in each capsule chamber 1 is released, it is transmittedin the outlet duct 11 and fully mixed by rotation, so that the movingspeed of the airflow arriving at the nozzle 3 is proper and theingredients are uniform.

Further preferably, by referring to FIG. 14, in one embodiment, thediameter of the outlet duct 11 gradually decreases from bottom to top,and a narrow neck 114 is formed before reaching the outlet, so that themoving speed of the airflow arriving at the nozzle 3 is proper and theingredients are uniform.

By referring to FIG. 18, it is another embodiment of the dry powderinhaler of the present invention. The multi-capsule chamber is composedof a first capsule chamber 1 a, a second capsule chamber 1 b, and athird capsule chamber 1 c, which are closely arranged into a triangle.The first actuator 2 a is arranged on one side of a line where the firstcapsule chamber 1 a and the second capsule chamber 1 b are connected,and the first actuator 2 a is provided with two needles 21 in the widthdirection, and the two needles can move to the multi-capsule chamber topuncture the capsules in the first capsule chamber 1 a and the secondcapsule chamber 1 b at the same time, and the second actuator 2 b isarranged on a side of the third capsule chamber 1 c away from the firstcapsule chamber 1 a and the second capsule chamber 1 b, and is movablein a direction perpendicular to the straight line where the firstcapsule chamber 1 a and the second capsule chamber 1 b lie to puncturethe capsule in the third capsule chamber 1 c.

This embodiment provides a medicine dispenser containing three activecomponents (or a mixture thereof) in a separated manner by providingthree capsule chambers, and an intake duct 14 is provided at the bottomof each capsule chamber 1, and no deflected intake duct group isprovided on the side or bottom of each capsule chamber. The arrangementof other components is the same as or similar to that in otherembodiments, and details are not described herein again.

Further preferably, by referring to FIG. 18, in one embodiment, thediameter of the bottom intake duct 14 of one capsule chamber 1 isdifferent from that of the other two capsule chambers, so that theintake airflow rate of the capsule chamber is different from that of theother capsule chambers.

In some cases, each component of the combined product needs to achieve aspecific particle distribution to maximize its effect. Since eachcomponent of the present invention is released separately in eachcorresponding capsule chamber 1, by adjusting structural characteristicssuch as the size, position, opening angle, and/or the number of theintake ducts 13, the intake ducts 14, and/or the air outlet duct 11,different aerodynamic parameters can be set for each capsule chamber 1,in order to maximize the therapeutic effect of each active ingredientunder the premise of simultaneous administration. In this embodiment,the size of the intake duct 14 at the bottom of the capsule chambers 1is adjusted to give different air flow rates to affect the particledistribution of the powder in the capsules.

By referring to FIG. 19, it is another embodiment of the dry powderinhaler of the present invention, the multi-capsule chamber 1 iscomposed of the first capsule chamber 1 a, the second capsule chamber 1b, the third capsule chamber 1 c and the fourth capsule chamber 1 d,which are arranged closely as a square. The first actuator 2 a and thesecond actuator 2 b are arranged on the central axis of the square andcan move from both sides to the middle, the first actuator 2 a and thesecond actuator 2 b comprises at least two needles 21 in the widthdirection so that the first actuator 2 a simultaneously punctures thecapsules in the first capsule chamber 1 a and the second capsule chamber1 b, and the second actuator 2 b simultaneously punctures the capsulesin the third capsule chamber 1 c and the fourth capsule chamber 1 d.

This embodiment provides a medicine dispenser containing four activecomponents (or a mixture thereof) in a separated manner by providingfour capsule chambers. Providing four capsule chambers results in ahigher requirement for the inhaler for the patient's inspiratory flow.In order to rotate and vibrate the capsule fully to release theinhalable powder, each capsule chamber 1 of this embodiment is providedwith a deflected intake duct group at the bottom of the capsule chamber,and the intake duct group is arranged as a fixed impeller to provide aspiral air flow from bottom to top when the user inhales, whicheffectively promotes the capsule's rotation and vibration to release theinhalable powder. The specific shape of the impeller structure is shownin FIG. 10.

The above are only the specific embodiments of the present invention andare not intended to limit the scope of the present invention. Anyequivalent change, modification and combination made by persons skilledin the art without departing from the concept and principle of thepresent invention shall fall within the protection of this application.

What is claimed is:
 1. Dry powder inhaler, comprising: capsule chambers(1), which are cylindrical chambers that can hold the capsule upright,the top of the capsule chambers (1) is open, and the bottom and/or theside walls of the capsule chambers (1) are provided with intake ductsventilating with the outside air; actuators (2), comprising punctureneedles (21), mounted for the user to operate to move toward the sidewalls of the capsule chambers (1) to puncture the capsules; nozzle (3),comprising an outlet duct (11) under the nozzle (3); wherein, the numberof the capsule chambers (1) is two to four, and all the capsule chambers(1) are arranged in parallel to form an integral multi-capsule chamber,the actuators (2) are mounted individually or in common among thecapsule chambers (1), and the actuators (2) are mounted with needles(21) in the width direction of the actuators (2), at least the number ofthe needles (21) is same as that of matching capsule chambers (1), ascreen cover (15) is mounted at the bottom of the outlet duct (11) underthe nozzle (3), and a screen (12) is fixed in the screen cover (15) andseparately connected to the top of the multi-capsule chamber, making thescreen (12) cover the top of all of the capsule chambers (1).
 2. The drypowder inhaler of claim 1, wherein each capsule chamber (1) is providedat its bottom and/or side wall with at least one deflected intake ductgroup, the deflected intake duct group comprises at least two deflectedintake ducts (13) which are arranged around the central axis of thecapsule chamber (1), and simultaneously deflect clockwise orcounterclockwise.
 3. The dry powder inhaler of claim 2, wherein thedeflected intake ducts (13) of the deflected intake duct group of eachcapsule chamber (1) have the same shape and size, and are evenlyarranged around a central axis of the capsule chamber (1).
 4. The drypowder inhaler of claim 3, wherein the deflected intake duct groupcomprises two deflected intake ducts (13) which are tangent to the sidewall of the capsule chamber (1).
 5. The dry powder inhaler of claim 2,wherein the intake ducts are provided on the capsule chamber (1) in thefollowing manner: a deflected intake duct group and/or direct intakeduct is provided at the bottom of the capsule chamber (1), and adeflected intake duct group is provided at the side wall of the capsulechamber, or, a deflected intake duct group is provided at the bottom ofthe capsule chamber (1), but no intake duct is provided on the side wallof the capsule chamber, or, no intake duct is provided at the bottom ofthe capsule chamber (1), but a deflected intake duct group is providedin the lower part of the side wall of the capsule chamber.
 6. The drypowder inhaler of claim 5, wherein the opening of the deflected intakeducts (13) on the side wall of the capsule chamber (1) has a long-stripshape, which is arranged longitudinally along the side wall.
 7. The drypowder inhaler of claim 5, wherein the deflected intake duct group isarranged at the bottom of the capsule chamber as a fixed impeller as awhole.
 8. The dry powder inhaler of claim 1, wherein the diameter of theoutlet duct (11) gradually decreases from bottom to top, and a narrowneck is formed before arriving at the nozzle (3), and two small holesventilating with the outside air are provided under the narrow neck ofthe outlet duct, and the small holes are symmetrically opened around butnot towards the central axis of the outlet duct (11).
 9. The dry powderinhaler of claim 1, wherein the size of the intake duct and/or topopening of at least one of the capsule chambers (1) is different fromthat of other of the capsule chambers (1).
 10. The dry powder inhaler ofclaim 2, wherein the lower part of the outlet duct (11) is divided by acentral baffle (111) to form some sub-ducts, which are respectivelyconnected to the top of each capsule chamber (1), each sub-ductgradually gathers from the top of each capsule chamber (1) from bottomto top toward the central baffle (111), and cross-sections thereofgradually narrow.
 11. The dry powder inhaler of claim 10, wherein thecross-sections of the sub-ducts gradually narrow first, and then remain.12. The dry powder inhaler of claim 10, wherein the cross-section of theoutlet duct (11) gradually increases in a direction from the top of thecentral baffle (111) toward the nozzle (3).
 13. The dry powder inhalerof claim 12, wherein the cross-section of the outlet duct (11) graduallyincreases first, and then remains.
 14. The dry powder inhaler of claim10, wherein a sub-duct comprises one or more sub-baffles (112), thesub-baffles (112) divide the sub-duct into narrower ducts, whichgradually gather from bottom to top from the top of each capsule chambertoward the central baffle.
 15. The dry powder inhaler of claim 14,wherein the height of the sub-baffles (112) is lower than that of thecentral baffle (111).
 16. The dry powder inhaler of claim 10, whereinthe cross-section of the sub-baffles (112) is arranged radially with thecenter baffle (111) as the center.
 17. The dry powder inhaler of claim16, wherein the number of capsule chambers (1) is two, and the shape ofthe cross-section of the sub-baffles (112) is X-shaped, which takes thecentral baffle (111) as the plane mirror symmetry.
 18. The dry powderinhaler of claim 17, wherein the air resistance of the dry powderinhaler is 0.0325 KPa^(0.5) minutes/liter.
 19. The dry powder inhaler ofclaim 17, wherein the length of the outlet duct (11) is 25-36 mm. 20.The dry powder inhaler of claim 1, wherein the multi-capsule chamber iscomposed of a first capsule chamber (1 a) and a second capsule chamber(1 b) which are closely arranged, and a first actuator (2 a) and asecond actuator (2 b) are arranged at both ends of the connecting linewhere the first capsule chamber (1 a) and the second capsule chamber (1b) are located, the first actuator (2 a) and the second actuator (2 b)can move from both sides to the middle so as to puncture the capsules inthe first capsule chamber (1 a) and the second capsule chamber (1 b),respectively.